Erhaltungstherapie mit Methadontabletten - Eine Übersicht
Erhaltungstherapie mit Methadontabletten - Eine Übersicht
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If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. You may also experience withdrawal symptoms.
As with all opioid drugs, it is necessary to adjust the dosing regimen for each patient individually, taking into account the patient's prior analgesic treatment experience. The following dosing recommendations should only be considered as suggested approaches to what is actually a series of clinical decisions over time rein the management of the pain of each individual patient.
When methadone is used with certain drugs, it may not work as well to treat your condition. This is because the amount of methadone rein your body may Beryllium decreased. Examples of these drugs include:
The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
Acute Pain – Maintenance patients on a stable dose of methadone Weltgesundheitsorganisation experience physical trauma, postoperative pain or other acute pain cannot be expected to derive analgesia from their existing dose of methadone. Such patients should be administered analgesics, including opioids, in doses that would otherwise be indicated for non-methadone-treated patients with similar painful conditions.
If these side effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
How to tell if the drug is working: You should have decreased pain, or your withdrawal symptoms should go away.
For people with a gastrointestinal (Us-soldat) obstruction: This drug can cause constipation and increase your risk of a GI obstruction. If you have a history of GI obstructions or you currently have one, you should Magnesiumsilikathydrat to your doctor about whether this drug is safe for you.
Do not take any medicine while using methadone hydrochloride tablets until you have first talked to your doctor or pharmacist. They will Beryllium able to tell you if it is safe to take other medicines while you are using methadone hydrochloride tablets.
These can Beryllium symptoms that you have taken too much (overdose of) methadone hydrochloride tablets, or the dose is too high for you. They can also Beryllium symptoms of a serious heart reaction. These symptoms can lead to serious problems or death if not treated right away.
The chance is higher if you are or have been addicted to or abused other medicines, street drugs, or alcohol, or if you have a history of mental problems.
Anxiety – Since methadone as used by tolerant patients at a constant maintenance dosage does not act as a tranquilizer, patients who are maintained on this drug will react to life problems and stresses with the same symptoms of anxiety as do other individuals.
Do not take other medicines with methadone hydrochloride tablets without first talking with your doctor.
Methadone undergoes hepatic N-demethylation by cytochrome P-450 isoforms, principally CYP3A4, CYP2B6, CYP2C19, and to a lesser extent by CYP2C9 and CYP2D6. Coadministration of methadone with inducers of these enzymes may result hinein Methadontabletten online zu verkaufen more rapid methadone metabolism, and potentially, decreased effects of methadone. Conversely, administration with CYP inhibitors may reduce metabolism and potentiate methadone's effects. Pharmacokinetics of methadone may Beryllium unpredictable when coadministered with drugs that are known to both induce and inhibit CYP enzymes.